What is GEN-TAAD?
GEN-TAAD is a large-scale research initiative focused on uncovering the genetic and molecular mechanisms underlying thoracic aortic aneurysms and dissections.
By combining genomic data, clinical information, and advanced molecular techniques, the project aims to better understand why some individuals develop life-threatening aortic disease, while others do not.
The ultimate goal is to move beyond generalised care toward personalised risk prediction and targeted treatment strategies.
Why this matters
Thoracic aortic dissections are life-threatening events with extremely high mortality if untreated. Current clinical decision-making is largely based on aortic diameter, a limited and often insufficient predictor of risk.
More than 85% of dissections occur below current surgical thresholds. Meaning high-risk patients are missed, while low-risk patients undergo unnecessary major surgery.
GEN-TAAD addresses this gap by developing more accurate, personalised approaches to risk prediction.
What we do
- Conduct large-scale genome-wide association studies (GWAS)
- Identify genetic variants linked to aortic disease risk
- Develop polygenic risk scores for personalised prediction
- Integrate genetic, clinical, and epidemiological data
- Perform single-cell and multi-omics analyses in aortic tissue
- Validate findings in cellular and experimental models
Scientific foundation
GEN-TAAD is built on a translational research framework that connects clinical patient data, large-scale genomic datasets, multi-omics analysis (including RNA sequencing), and functional validation in stem cell and animal models.
This integrated approach allows us to move from genetic discovery → biological understanding → clinical application.
Impact
For individuals
Earlier identification of those at high risk of aortic complications.
For researchers
New insights into disease mechanisms and therapeutic targets.
For healthcare
Potential reduction in unnecessary surgeries and improved outcomes.
For society
A shift toward precision medicine in cardiovascular disease.
Other work from TARGet.
After the Storm
Understanding the silent, often invisible experience of recovery beyond survival.
Learn more →
SUKH Healing Garden
Nature-inspired environments for recovery, wellbeing, and resilience.
Learn more →
APECx Study
Understanding global cardiac surgery practices to improve outcomes and standardise care worldwide.
Learn more →