How does cholesterol damage arteries?

High LDL cholesterol contributes to a process called atherosclerosis.

In atherosclerosis, cholesterol particles enter the artery wall and trigger inflammation. Over time, fatty deposits called plaques develop.

These plaques:

  • Narrow the arteries
  • Reduce blood flow
  • Make blood vessels less flexible

If a plaque ruptures, a blood clot can form and suddenly block blood flow.

This can lead to:

  • Heart attack
  • Stroke
  • Transient ischemic attack (TIA)
  • Peripheral artery disease

Atherosclerosis develops gradually over many years and often begins long before symptoms appear.